N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide BRD73954
BRD73954
CAS: 1440209-96-0
Molecular Formula: C16H16N2O3
N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide BRD73954 - Names and Identifiers
N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide BRD73954 - Physico-chemical Properties
| Molecular Formula | C16H16N2O3 |
| Molar Mass | 284.31 |
| Density | 1.245±0.06 g/cm3(Predicted) |
| Melting Point | 172-175oC |
| Solubility | DMSO: ≥ 35 mg/mL |
| Appearance | Solid |
| Color | Off-White |
| pKa | 8.56±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| In vitro study | As compared to the other class I and II histone deacetylases (HDACs) (HDAC1, 12 μM; HDAC2, 9 μM; HDAC3, 23μM; HDAC4, >33 μM; HDAC5, >33 μM; HDAC7, 13 μM; HDAC8, 120 nM; HDAC9, >33 μM), BRD73954 maintains excellent selectivity toward HDAC6 and HDAC8 with IC50 of 36 nM and 120 nM, respectively. Treatment with BRD73954 results in a robust increase in α -tubulin acetylation. |
N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide BRD73954 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.517 ml | 17.586 ml | 35.173 ml |
| 5 mM | 0.703 ml | 3.517 ml | 7.035 ml |
| 10 mM | 0.352 ml | 1.759 ml | 3.517 ml |
| 5 mM | 0.07 ml | 0.352 ml | 0.703 ml |
Last Update：2024-01-02 23:10:35
N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide BRD73954 - Reference Information
| trait | BRD73954 was white to off-white solid in appearance. |
| Use | BRD73954 is a potent small molecule inhibitor of HDAC6 and hdac8. |
| biological activity | BRD73954 is a potent and selective HDAC inhibitor, the IC50 for HDAC6 and HDAC8 were 36 nM and 120 nM, respectively. |
Last Update：2024-04-09 20:45:29
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View History
N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide BRD73954
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Phosphorothioic acid O,O,O-tri(4-isocyanatophenyl) ester
2-氨基-3-硝基苯甲酸乙酯
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ART-CHEM-BB B020019
9008-02-0
4-(Aminomethyl)-2,6-bis(1-pyrrolidinylmethyl)phenol
TERT-BUTYL 2-(CHLOROSULFONYL)-1H-INDOLE-1-CARBOXYLATE
(4-AMINO-PHENYL)-THIOUREA
2-(3-四氢吡喃基)乙酸
Phosphorothioic acid O,O,O-tri(4-isocyanatophenyl) ester
2-氨基-3-硝基苯甲酸乙酯
1-METHYL-3-OXOQUINUCLIDIUM IODIDE
ART-CHEM-BB B020019
9008-02-0
4-(Aminomethyl)-2,6-bis(1-pyrrolidinylmethyl)phenol
TERT-BUTYL 2-(CHLOROSULFONYL)-1H-INDOLE-1-CARBOXYLATE
(4-AMINO-PHENYL)-THIOUREA